Cyclophosphamide For Injection + Metronidazole Interaction

Description

Monitor for increased toxicities in patients receiving radiation therapy or drugs known to cause: • Myelosuppression and/or immunosuppression [ see Warnings and Precautions ( 5.1 ) ] • Nephrotoxicity including hemorrhagic cystitis [ see Warnings and Precautions ( 5.2 ) ] • Cardiotoxicity [ see Warnings and Precautions ( 5.3 ) ] • Pulmonary toxicity [ see Warnings and Precautions ( 5.4 ) ] • Secondary malignancies [ see Warnings and Precautions ( 5.5 ) ] • Hepatotoxicity including liver necrosis and VOD [ see Warnings and Precautions ( 5.6 ) ] 7.3 Effect of Cyclophosphamide on Other Drugs Metronidazole Acute encephalopathy has been reported in a patient receiving cyclophosphamide and metronidazole. Monitor for neurologic toxicities in patients receiving metronidazole.