Does Dextroamphetamine Interact with Mao Inhibitors?
CDI records a contraindicated classification for Dextroamphetamine and Mao Inhibitors. The stored summary is: MAOIs slow amphetamine metabolism, increasing norepinephrine release and causing hypertensive crisis, toxic neurological effects, and potentially fatal malignant hyperpyrexia. The mechanism involves inhibition of amphetamine metabolism leading to increased monoamine release from adrenergic nerve endings. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Dextroamphetamine Class
- Central Nervous System Stimulant
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of amphetamine metabolism leading to increased monoamine release from adrenergic nerve endings
What To Tell Your Doctor or Pharmacist
If you are taking Dextroamphetamine and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider