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Does Drugs That Prolong Qtc Interval Interact with Ziprasidone?

Drugs That Prolong Qtc Interval and Ziprasidone have a contraindicated drug interaction according to U.S. FDA drug labeling data. Ziprasidone should not be used in combination with other drugs that have demonstrated QT prolongation due to risk of serious cardiac arrhythmias. The mechanism involves combined qt prolongation effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ziprasidone Class
Atypical Antipsychotic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Drugs That Prolong Qtc Interval and Ziprasidone occurs because combined qt prolongation effects. Clinically, this means ziprasidone should not be used in combination with other drugs that have demonstrated qt prolongation due to risk of serious cardiac arrhythmias. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Drugs That Prolong Qtc Interval and your doctor is considering prescribing Ziprasidone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Drugs That Prolong Qtc Interval(Kyleena)+💊 Ziprasidone(Geodon)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Atypical Antipsychotic
Source
NLP:ziprasidone

What this means in plain English

Ziprasidone should not be used in combination with other drugs that have demonstrated QT prolongation due to risk of serious cardiac arrhythmias.

About Drugs That Prolong Qtc Interval and Ziprasidone

Ziprasidone is an Atypical Antipsychotic. You may recognize them by the brand names Kyleena and Geodon. Ziprasidone is taken by mouth. Ziprasidone additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Combined QT prolongation effects"

📖 Source: NLP:ziprasidone

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.