Does Emtricitabine And Tenofovir Alafenamide Interact with Atazanavir And Cobicistat?
Emtricitabine And Tenofovir Alafenamide and Atazanavir And Cobicistat have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration increases TAF concentration. Not recommended in pediatric patients weighing 14 to <35 kg. The mechanism involves p-gp and bcrp inhibition leading to increased taf absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Emtricitabine And Tenofovir Alafenamide Class
- Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Atazanavir And Cobicistat Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Emtricitabine And Tenofovir Alafenamide and Atazanavir And Cobicistat occurs because p-gp and bcrp inhibition leading to increased taf absorption. Clinically, this means coadministration increases taf concentration. not recommended in pediatric patients weighing 14 to <35 kg. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Emtricitabine And Tenofovir Alafenamide and your doctor is considering prescribing Atazanavir And Cobicistat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider