Does Glipizide And Metformin Hydrochloride Interact with Probenecid?
CDI records a moderate classification for Glipizide And Metformin Hydrochloride and Probenecid. The stored summary is: Probenecid may potentiate the hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia. The mechanism involves potentiation of hypoglycemic effect; highly protein-bound. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Glipizide And Metformin Hydrochloride Class
- Sulfonylurea
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Potentiation of hypoglycemic effect; highly protein-bound
What To Tell Your Doctor or Pharmacist
If you are taking Glipizide And Metformin Hydrochloride and your doctor is considering prescribing Probenecid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider