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Does Human Immunoglobulin G Interact with Measles Vaccine?

Human Immunoglobulin G and Measles Vaccine have a moderate drug interaction according to U.S. FDA drug labeling data. Immunoglobulin may transiently impair efficacy of live attenuated measles vaccine due to interference with active antibody response from passively acquired antibodies. The mechanism involves passive antibodies interfere with active immune response to live vaccine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Human Immunoglobulin G Class
Human Immunoglobulin G
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Human Immunoglobulin G and Measles Vaccine occurs because passive antibodies interfere with active immune response to live vaccine. Clinically, this means immunoglobulin may transiently impair efficacy of live attenuated measles vaccine due to interference with active antibody response from passively acquired antibodies. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Human Immunoglobulin G and your doctor is considering prescribing Measles Vaccine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Human Immunoglobulin G(Qivigy Kthm)+💊 Measles Vaccine(M-M-R II)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Human Immunoglobulin G
Drug B class
—
Source
NLP:human immunoglobulin g

What this means in plain English

Immunoglobulin may transiently impair efficacy of live attenuated measles vaccine due to interference with active antibody response from passively acquired antibodies.

About Human Immunoglobulin G and Measles Vaccine

Human Immunoglobulin G is a Human Immunoglobulin G. You may recognize them by the brand names Qivigy Kthm and M-M-R II. Human Immunoglobulin G is given by intravenous (IV) infusion. Human Immunoglobulin G additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Passive antibodies interfere with active immune response to live vaccine"

📖 Source: NLP:human immunoglobulin g

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.