Does Infliximab Axxq Interact with Infliximab?
Infliximab Axxq and Infliximab have a unknown drug interaction according to U.S. FDA drug labeling data. Concomitant MTX use may decrease the incidence of anti-drug antibody production and increase infliximab product concentrations. Serum infliximab concentrations appeared to be unaffected by baseline use of medications for the treatment of CD including corticosteroids, antibiotics (metronidazole or ciprofloxacin) and aminosalicylates. Therefore, it is expected that for a molecule that antagonizes cytokine activity, such as infliximab products, the formation of CYP450 enzymes could be normalized. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Infliximab Axxq Class
- Tumor Necrosis Factor Blocker
- Infliximab Class
- Tumor Necrosis Factor Blocker
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Infliximab Axxq and your doctor is considering prescribing Infliximab (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider