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Does Itraconazole Interact with Eliglustat?

Itraconazole and Eliglustat have a contraindicated drug interaction according to U.S. FDA drug labeling data. Coadministration is contraindicated in poor or intermediate CYP2D6 metabolizers and in subjects taking strong or moderate CYP2D6 inhibitors. Itraconazole increases plasma concentrations. The mechanism involves cyp2d6 interaction; increased plasma concentration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Itraconazole Class
Azole Antifungal
Eliglustat Class
Glucosylceramide Synthase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Itraconazole and Eliglustat occurs because cyp2d6 interaction; increased plasma concentration. Clinically, this means coadministration is contraindicated in poor or intermediate cyp2d6 metabolizers and in subjects taking strong or moderate cyp2d6 inhibitors. itraconazole increases plasma concentrations. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Itraconazole and your doctor is considering prescribing Eliglustat (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Itraconazole+💊 Eliglustat(Cerdelga)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Glucosylceramide Synthase Inhibitor
Source
NLP:itraconazole

What this means in plain English

Coadministration is contraindicated in poor or intermediate CYP2D6 metabolizers and in subjects taking strong or moderate CYP2D6 inhibitors. Itraconazole increases plasma concentrations.

What the FDA label says

"CYP2D6 interaction; increased plasma concentration"

📖 Source: NLP:itraconazole

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.