Does Itraconazole Interact with Loperamide?
The itraconazole capsule label lists loperamide in its interaction table and advises monitoring for adverse reactions; a clinician may need to reduce the concomitant drug’s dose.
Label evidence and limitations
Named-drug label evidence. The original extracted text ran the neighboring aprepitant name into the loperamide entry. This comparison follows the loperamide table row and does not validate CDI’s severity rating.
Product scope: Oral itraconazole capsules; the loperamide row of the interaction table.
Read the DailyMed label: ITRACONAZOLE CAPSULES, USP Rx Only
Section: Drug Interactions — Gastrointestinal Drugs table. Compared version 27, label date 2026-09-17. The linked label may be updated after this comparison.
The original record has no saved label identifier. This comparison uses a label located during the source check; it does not recover the original extraction source.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Moderate
- Itraconazole Class
- Azole Antifungal
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Itraconazole and your doctor is considering prescribing Loperamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider