Does Lamivudine And Tenofovir Disoproxil Fumarate Interact with Ledipasvir And Sofosbuvir?
Lamivudine And Tenofovir Disoproxil Fumarate and Ledipasvir And Sofosbuvir have a major drug interaction according to U.S. FDA drug labeling data. Increases tenofovir exposure. Without protease inhibitor/ritonavir, monitor for tenofovir adverse reactions. With protease inhibitor/ritonavir or cobicistat, consider alternative therapy or monitor closely. The mechanism involves increases tenofovir exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Lamivudine And Tenofovir Disoproxil Fumarate Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Ledipasvir And Sofosbuvir Class
- Hepatitis C Virus NS5A Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lamivudine And Tenofovir Disoproxil Fumarate and Ledipasvir And Sofosbuvir occurs because increases tenofovir exposure. Clinically, this means increases tenofovir exposure. without protease inhibitor/ritonavir, monitor for tenofovir adverse reactions. with protease inhibitor/ritonavir or cobicistat, consider alternative therapy or monitor closely. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Lamivudine And Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Ledipasvir And Sofosbuvir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider