Does Levoleucovorin Calcium Interact with Sulfamethoxazole And Trimethoprim?
Levoleucovorin Calcium and Sulfamethoxazole And Trimethoprim have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use for acute treatment of Pneumocystis jiroveci pneumonia in HIV patients was associated with increased treatment failure and morbidity in placebo-controlled study. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Sulfamethoxazole And Trimethoprim Class
- Sulfonamide Antimicrobial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Levoleucovorin Calcium and your doctor is considering prescribing Sulfamethoxazole And Trimethoprim (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider