Does Levothyroxine Interact with Sodium Polystyrene Sulfonate?
CDI records a moderate classification for Levothyroxine and Sodium Polystyrene Sulfonate. The stored summary is: Sodium Polystyrene Sulfonate may bind thyroxine and decrease its gastrointestinal absorption. Administer at least 3 hours before or after Sodium Polystyrene Sulfonate. The mechanism involves binding to thyroxine reduces gastrointestinal absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sodium Polystyrene Sulfonate Class
- Potassium Binder
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Binding to thyroxine reduces gastrointestinal absorption
What To Tell Your Doctor or Pharmacist
If you are taking Levothyroxine and your doctor is considering prescribing Sodium Polystyrene Sulfonate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider