Does Sodium Polystyrene Sulfonate Interact with Magnesium Hydroxide?
CDI records a contraindicated classification for Sodium Polystyrene Sulfonate and Magnesium Hydroxide. The stored summary is: Should not be administered with sodium polystyrene sulfonate. Risk of systemic alkalosis and seizures reported. The mechanism involves cation exchange interaction; magnesium hydroxide reduces resin's potassium exchange capability. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Sodium Polystyrene Sulfonate Class
- Potassium Binder
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cation exchange interaction; magnesium hydroxide reduces resin's potassium exchange capability
What To Tell Your Doctor or Pharmacist
If you are taking Sodium Polystyrene Sulfonate and your doctor is considering prescribing Magnesium Hydroxide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider