Does Live Attenuated Vaccines Interact with Rimantadine Hydrochloride?
Live Attenuated Vaccines and Rimantadine Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Potential interference between products. LAIV should not be administered until 48 hours after rimantadine cessation; rimantadine should not be given until 2 weeks after LAIV unless medically indicated. The mechanism involves potential for antiviral drugs to inhibit replication of live vaccine virus. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Live Attenuated Vaccines and Rimantadine Hydrochloride occurs because potential for antiviral drugs to inhibit replication of live vaccine virus. Clinically, this means potential interference between products. laiv should not be administered until 48 hours after rimantadine cessation; rimantadine should not be given until 2 weeks after laiv unless medically indicated. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Live Attenuated Vaccines and your doctor is considering prescribing Rimantadine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider