Losartan Potassium And Hydrochlorothiazide + Fluconazole Interaction
Unknowninteraction on record
Description
Fluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of losartan by approximately 70% following multiple doses. Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration.
Source: FDA drug label - losartan potassium and hydrochlorothiazide