Home›Lumacaftor And Ivacaftor›Lumacaftor And Ivacaftor + Rifampin

Does Lumacaftor And Ivacaftor Interact with Rifampin?

Lumacaftor And Ivacaftor and Rifampin have a major drug interaction according to U.S. FDA drug labeling data. Strong CYP3A inducer decreases ivacaftor exposure by 57%, reducing ORKAMBI effectiveness. Co-administration not recommended. The mechanism involves cyp3a induction decreases ivacaftor exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Lumacaftor And Ivacaftor Class
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Rifampin Class
Rifamycin Antibacterial
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lumacaftor And Ivacaftor and Rifampin occurs because cyp3a induction decreases ivacaftor exposure. Clinically, this means strong cyp3a inducer decreases ivacaftor exposure by 57%, reducing orkambi effectiveness. co-administration not recommended. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Lumacaftor And Ivacaftor and your doctor is considering prescribing Rifampin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lumacaftor And Ivacaftor(Orkambi)+💊 Rifampin(Rifadin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Drug B class
Rifamycin Antibacterial
Source
NLP:lumacaftor and ivacaftor

What this means in plain English

Strong CYP3A inducer decreases ivacaftor exposure by 57%, reducing ORKAMBI effectiveness. Co-administration not recommended.

About Lumacaftor And Ivacaftor and Rifampin

Lumacaftor And Ivacaftor is a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, while Rifampin is a Rifamycin Antibacterial. You may recognize them by the brand names Orkambi and Rifadin. Both medications are taken by mouth.

What the FDA label says

"CYP3A induction decreases ivacaftor exposure"

📖 Source: NLP:lumacaftor and ivacaftor

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Lumacaftor And Ivacaftor and Rifampin against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.