Lumacaftor And Ivacaftor has 21 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rifampin, St. John'S Wort, Clarithromycin. Patients taking Lumacaftor And Ivacaftor should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Major
- 2
- Moderate
- 6
Major (2)
- Lumacaftor And Ivacaftor + Rifampin— Strong CYP3A inducer decreases ivacaftor exposure by 57%, reducing ORKAMBI effectiveness. Co-administration not recommen…
- Lumacaftor And Ivacaftor + St. John'S Wort— Strong CYP3A inducer significantly reduces ivacaftor exposure and ORKAMBI therapeutic effectiveness. Co-administration n…
Moderate (6)
- Lumacaftor And Ivacaftor + Clarithromycin— Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI.
- Lumacaftor And Ivacaftor + Itraconazole— Strong CYP3A inhibitor increases ivacaftor exposure 4.3-fold. Dosage adjustment needed when initiating ORKAMBI in patien…
- Lumacaftor And Ivacaftor + Ketoconazole— Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI.
- Lumacaftor And Ivacaftor + Posaconazole— Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI.
- Lumacaftor And Ivacaftor + Telithromycin— Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI.
- Lumacaftor And Ivacaftor + Voriconazole— Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI.