Does Lumacaftor And Ivacaftor Interact with Itraconazole?
Lumacaftor And Ivacaftor and Itraconazole have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP3A inhibitor increases ivacaftor exposure 4.3-fold. Dosage adjustment needed when initiating ORKAMBI in patients taking itraconazole. The mechanism involves cyp3a inhibition increases ivacaftor exposure; lumacaftor induction effect mitigates at steady-state. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Lumacaftor And Ivacaftor Class
- Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
- Itraconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lumacaftor And Ivacaftor and Itraconazole occurs because cyp3a inhibition increases ivacaftor exposure; lumacaftor induction effect mitigates at steady-state. Clinically, this means strong cyp3a inhibitor increases ivacaftor exposure 4.3-fold. dosage adjustment needed when initiating orkambi in patients taking itraconazole. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lumacaftor And Ivacaftor and your doctor is considering prescribing Itraconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider