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Does Mao Inhibitors Interact with Dextroamphetamine?

Mao Inhibitors and Dextroamphetamine have a contraindicated drug interaction according to U.S. FDA drug labeling data. MAOIs slow amphetamine metabolism, increasing norepinephrine release and causing hypertensive crisis, toxic neurological effects, and potentially fatal malignant hyperpyrexia. The mechanism involves inhibition of amphetamine metabolism leading to increased monoamine release from adrenergic nerve endings. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Dextroamphetamine Class
Central Nervous System Stimulant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Mao Inhibitors and Dextroamphetamine occurs because inhibition of amphetamine metabolism leading to increased monoamine release from adrenergic nerve endings. Clinically, this means maois slow amphetamine metabolism, increasing norepinephrine release and causing hypertensive crisis, toxic neurological effects, and potentially fatal malignant hyperpyrexia. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Mao Inhibitors and your doctor is considering prescribing Dextroamphetamine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Mao Inhibitors+💊 Dextroamphetamine(Dextroamphetamine)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Central Nervous System Stimulant
Source
NLP:dextroamphetamine

What this means in plain English

MAOIs slow amphetamine metabolism, increasing norepinephrine release and causing hypertensive crisis, toxic neurological effects, and potentially fatal malignant hyperpyrexia.

What the FDA label says

"Inhibition of amphetamine metabolism leading to increased monoamine release from adrenergic nerve endings"

📖 Source: NLP:dextroamphetamine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.