Mao Inhibitors + Memantine Hydrochloride Interaction
Moderateinteraction on record
Description
Carbonic anhydrase inhibitors alter urine pH towards alkaline conditions, which may reduce memantine clearance by about 80% and lead to drug accumulation and increased adverse effects.
Mechanism
Alteration of urine pH to alkaline conditions reduces memantine renal clearance
Source: NLP:memantine hydrochloride oral