Mao Inhibitors + Tramadol Hydrochloride And Acetaminophen Interaction
Majorinteraction on record
Description
Increase tramadol plasma concentration, potentially causing seizures, serotonin syndrome, opioid toxicity, and potentially fatal respiratory depression.
Mechanism
Inhibition of CYP3A4 metabolism of tramadol, increasing M1 formation via CYP2D6
Source: NLP:tramadol hydrochloride and acetaminophen