Does Meperidine Hydrochloride Interact with Linezolid?
CDI records a contraindicated classification for Meperidine Hydrochloride and Linezolid. The stored summary is: Meperidine is contraindicated in patients receiving MAOIs. Can cause unpredictable, severe, and occasionally fatal reactions including coma, respiratory depression, serotonin syndrome, convulsions, and hypertension. The mechanism involves unclear; may be related to preexisting hyperphenylalaninemia. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Linezolid Class
- Oxazolidinone Antibacterial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Unclear; may be related to preexisting hyperphenylalaninemia
What To Tell Your Doctor or Pharmacist
If you are taking Meperidine Hydrochloride and your doctor is considering prescribing Linezolid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider