Does Meperidine Hydrochloride Interact with Monoamine Oxidase Inhibitors Maois?
CDI records a contraindicated classification for Meperidine Hydrochloride and Monoamine Oxidase Inhibitors Maois. The stored summary is: Meperidine is contraindicated with MAOIs or within 14 days of stopping them. Can cause unpredictable, severe, and occasionally fatal reactions including serotonin syndrome, respiratory depression, coma, and hypertensive crisis. The mechanism involves unclear mechanism, possibly related to preexisting hyperphenylalaninemia. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Unclear mechanism, possibly related to preexisting hyperphenylalaninemia
What To Tell Your Doctor or Pharmacist
If you are taking Meperidine Hydrochloride and your doctor is considering prescribing Monoamine Oxidase Inhibitors Maois (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider