Does Monoamine Oxidase Inhibitors Maois Interact with Morphine Sulfate?
CDI records a contraindicated classification for Monoamine Oxidase Inhibitors Maois and Morphine Sulfate. The stored summary is: Do not use within 14 days of stopping MAOI treatment; may manifest as serotonin syndrome or opioid toxicity including respiratory depression and coma. The mechanism involves serotonergic interaction or opioid toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Serotonergic interaction or opioid toxicity
What To Tell Your Doctor or Pharmacist
If you are taking Monoamine Oxidase Inhibitors Maois and your doctor is considering prescribing Morphine Sulfate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider