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Does Morphine Sulfate Interact with Methylene Blue?

CDI records a contraindicated classification for Morphine Sulfate and Methylene Blue. The stored summary is: Do not use morphine sulfate with intravenous methylene blue. MAOI interaction may manifest as serotonin syndrome or opioid toxicity. The mechanism involves maoi activity causing serotonin syndrome or opioid toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Contraindicated
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

MAOI activity causing serotonin syndrome or opioid toxicity

What To Tell Your Doctor or Pharmacist

If you are taking Morphine Sulfate and your doctor is considering prescribing Methylene Blue (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Morphine Sulfate(Kadian)+💊 Methylene Blue(Provayblue)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

CDI classifies this record as contraindicated. Confirm the applicable product labeling with your prescriber or pharmacist.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:morphine sulfate

What this means in plain English

Do not use morphine sulfate with intravenous methylene blue. MAOI interaction may manifest as serotonin syndrome or opioid toxicity.

About Morphine Sulfate and Methylene Blue

You may recognize them by the brand names Kadian and Provayblue. Both Morphine Sulfate and Methylene Blue carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:morphine sulfate

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.