Does Moxifloxacin Hydrochloride Tablets 400 Mg Interact with Didanosine?
CDI records a moderate classification for Moxifloxacin Hydrochloride Tablets 400 Mg and Didanosine. The stored summary is: Buffered didanosine tablets contain divalent and trivalent cations that form chelates with moxifloxacin, substantially decreasing moxifloxacin absorption. Separate dosing by at least 4 hours before or 8 hours after. The mechanism involves chelation with multivalent cations reduces drug absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Chelation with multivalent cations reduces drug absorption
What To Tell Your Doctor or Pharmacist
If you are taking Moxifloxacin Hydrochloride Tablets 400 Mg and your doctor is considering prescribing Didanosine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider