Does Moxifloxacin Hydrochloride Tablets 400 Mg Interact with Didanosine?
Moxifloxacin Hydrochloride Tablets 400 Mg and Didanosine have a moderate drug interaction according to U.S. FDA drug labeling data. Buffered didanosine tablets contain divalent and trivalent cations that form chelates with moxifloxacin, substantially decreasing moxifloxacin absorption. Separate dosing by at least 4 hours before or 8 hours after. The mechanism involves chelation with multivalent cations reduces drug absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Moxifloxacin Hydrochloride Tablets 400 Mg and Didanosine occurs because chelation with multivalent cations reduces drug absorption. Clinically, this means buffered didanosine tablets contain divalent and trivalent cations that form chelates with moxifloxacin, substantially decreasing moxifloxacin absorption. separate dosing by at least 4 hours before or 8 hours after. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Moxifloxacin Hydrochloride Tablets 400 Mg and your doctor is considering prescribing Didanosine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider