Nsaids + Losartan Potassium And Hydrochlorothiazide Interaction
Majorinteraction on record
Description
May result in deterioration of renal function including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. Antihypertensive effect may be attenuated.
Mechanism
NSAIDs reduce renal function when combined with angiotensin II receptor antagonists and diuretics; reduce diuretic and antihypertensive effects
Source: NLP:losartan potassium and hydrochlorothiazide