Does Olanzapine And Samidorphan L Malate Interact with Mao Inhibitors?
Moderate interaction. Concomitant use increases olanzapine AUC and Cmax, which may increase the risk of LYBALVI adverse reactions. Consider reducing the dosage of olanzapine component.
Source & how this summary was prepared
This interaction summary was extracted from FDA drug labeling through openFDA, using automated processing and AI assistance. NIH/NLM RxNorm helps organize drug names.
Read the saved source label on DailyMed →
A separate current-label comparison has not been recorded for this page. Read about our extraction process.
- Interaction classification
- Moderate
- Olanzapine And Samidorphan L Malate Class
- Atypical Antipsychotic
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How this interaction works
CYP1A2-mediated inhibition increasing olanzapine exposure
What To Tell Your Doctor or Pharmacist
If you are taking Olanzapine And Samidorphan L Malate and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider