Does Oral Anticoagulants Interact with Levothyroxine And Liothyronine?
CDI records a major classification for Oral Anticoagulants and Levothyroxine And Liothyronine. The stored summary is: Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, impairing compensatory synthesis. Patients may require reduced anticoagulant dosage when starting thyroid replacement. The mechanism involves increased catabolism of vitamin k-dependent clotting factors. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Levothyroxine And Liothyronine Class
- l-Triiodothyronine
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased catabolism of vitamin K-dependent clotting factors
What To Tell Your Doctor or Pharmacist
If you are taking Oral Anticoagulants and your doctor is considering prescribing Levothyroxine And Liothyronine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider