Does Oral Contraceptives Interact with Omaveloxolone?
CDI records a major classification for Oral Contraceptives and Omaveloxolone. The stored summary is: Omaveloxolone weakly induces CYP3A4, which may reduce the efficacy of hormonal contraceptives. Avoid concomitant use with combined hormonal contraceptives, implants, and progestin-only pills. The mechanism involves weak cyp3a4 induction reduces hormonal contraceptive exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
Saved label reference on DailyMed. This identifier has not been checked here as support for the current claim.
- Stored CDI classification
- Major
- Omaveloxolone Class
- Cytochrome P450 3A4 Inducers
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Weak CYP3A4 induction reduces hormonal contraceptive exposure
What To Tell Your Doctor or Pharmacist
If you are taking Oral Contraceptives and your doctor is considering prescribing Omaveloxolone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider