Does Oxycodone And Aspirin Interact with Mao Inhibitors?
Oxycodone And Aspirin and Mao Inhibitors have a moderate drug interaction according to U.S. FDA drug labeling data. Aspirin may diminish hypotensive and hyponatremic effects of ACE inhibitors through indirect effect on renin-angiotensin conversion pathway. The mechanism involves inhibition of renin-angiotensin conversion pathway. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Oxycodone And Aspirin Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Oxycodone And Aspirin and Mao Inhibitors occurs because inhibition of renin-angiotensin conversion pathway. Clinically, this means aspirin may diminish hypotensive and hyponatremic effects of ace inhibitors through indirect effect on renin-angiotensin conversion pathway. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Oxycodone And Aspirin and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider