Does Pentazocine Hydrochloride And Naloxone Hydrochloride Interact with Metaxalone?
CDI records a moderate classification for Pentazocine Hydrochloride And Naloxone Hydrochloride and Metaxalone. The stored summary is: Muscle relaxant affecting serotonergic system may cause serotonin syndrome; careful observation required. The mechanism involves serotonin neurotransmitter system interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Pentazocine Hydrochloride And Naloxone Hydrochloride Class
- Partial Opioid Agonist/Antagonist
- Metaxalone Class
- Muscle Relaxant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Serotonin neurotransmitter system interaction
What To Tell Your Doctor or Pharmacist
If you are taking Pentazocine Hydrochloride And Naloxone Hydrochloride and your doctor is considering prescribing Metaxalone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider