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Does Pyridoxine Hydrochloride Interact with Levodopa?

Pyridoxine Hydrochloride and Levodopa have a contraindicated drug interaction according to U.S. FDA drug labeling data. Pyridoxine antagonizes the action of levodopa. Should not be given concurrently unless levodopa is in a preparation containing carbidopa. The mechanism involves pyridoxine antagonizes levodopa action. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Levodopa Class
Aromatic Amino Acid
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Pyridoxine Hydrochloride and Levodopa occurs because pyridoxine antagonizes levodopa action. Clinically, this means pyridoxine antagonizes the action of levodopa. should not be given concurrently unless levodopa is in a preparation containing carbidopa. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Pyridoxine Hydrochloride and your doctor is considering prescribing Levodopa (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Pyridoxine Hydrochloride(Irospan Tablet)+💊 Levodopa(Inbrija)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Aromatic Amino Acid
Source
NLP:pyridoxine hydrochloride

What this means in plain English

Pyridoxine antagonizes the action of levodopa. Should not be given concurrently unless levodopa is in a preparation containing carbidopa.

About Pyridoxine Hydrochloride and Levodopa

Levodopa is an Aromatic Amino Acid. You may recognize them by the brand names Lactocal and Inbrija. Pyridoxine Hydrochloride is given by intramuscular injection, whereas Levodopa is inhaled.

What the FDA label says

"Pyridoxine antagonizes levodopa action"

📖 Source: NLP:pyridoxine hydrochloride

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.