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Does Selegiline Interact with Desvenlafaxine?

Selegiline and Desvenlafaxine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI. The mechanism involves inhibition of monoamine oxidase increases serotonergic activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Selegiline Class
Monoamine Oxidase Inhibitor
Desvenlafaxine Class
Serotonin and Norepinephrine Reuptake Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Selegiline and Desvenlafaxine occurs because inhibition of monoamine oxidase increases serotonergic activity. Clinically, this means concomitant use increases risk of serotonin syndrome. contraindicated with maoi or within 14 days of stopping maoi. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Selegiline and your doctor is considering prescribing Desvenlafaxine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Selegiline(Emsam)+💊 Desvenlafaxine(Desvenlafaxine)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Monoamine Oxidase Inhibitor
Drug B class
Serotonin and Norepinephrine Reuptake Inhibitor
Source
NLP:desvenlafaxine

What this means in plain English

Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.

What the FDA label says

"Inhibition of monoamine oxidase increases serotonergic activity"

📖 Source: NLP:desvenlafaxine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.