Does Spironolactone And Hydrochlorothiazide Interact with Lithium?
CDI records a contraindicated classification for Spironolactone And Hydrochlorothiazide and Lithium. The stored summary is: Diuretics reduce renal clearance of lithium and add high risk of lithium toxicity. Lithium generally should not be given with diuretics. The mechanism involves reduced renal clearance of lithium. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Spironolactone And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced renal clearance of lithium
What To Tell Your Doctor or Pharmacist
If you are taking Spironolactone And Hydrochlorothiazide and your doctor is considering prescribing Lithium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider