Spironolactone And Hydrochlorothiazide has 22 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Abiraterone, Lithium, Mitotane. Patients taking Spironolactone And Hydrochlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Contraindicated
- 3
- Major
- 9
- Moderate
- 10
Contraindicated (3)
- Spironolactone And Hydrochlorothiazide + Abiraterone— Spironolactone binds to androgen receptor and may increase PSA levels; concomitant use is not recommended.
- Spironolactone And Hydrochlorothiazide + Lithium— Diuretics reduce renal clearance of lithium and add high risk of lithium toxicity. Lithium generally should not be given…
- Spironolactone And Hydrochlorothiazide + Mitotane— Avoid concomitant use; spironolactone reduces mitotane plasma levels.
Major (9)
- Spironolactone And Hydrochlorothiazide + Aldosterone— Drug interactions ACE inhibitors, Angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, hepa…
- Spironolactone And Hydrochlorothiazide + Angiotensin Ii— Concomitant administration may lead to severe hyperkalemia.
- Spironolactone And Hydrochlorothiazide + Cholestyramine Light— Hyperkalemic metabolic acidosis has been reported with concurrent use.
- Spironolactone And Hydrochlorothiazide + Digoxin— Spironolactone increases digoxin half-life, leading to increased serum levels and potential digitalis toxicity; electrol…
- Spironolactone And Hydrochlorothiazide + Heparin— Concomitant administration may lead to severe hyperkalemia.
- Spironolactone And Hydrochlorothiazide + Indomethacin— Combination with potassium-sparing diuretics has been associated with severe hyperkalemia; may reduce diuretic effects.
- Spironolactone And Hydrochlorothiazide + Low Molecular Weight Heparin— Concomitant administration may lead to severe hyperkalemia.
- Spironolactone And Hydrochlorothiazide + Mao Inhibitors— Concomitant administration may lead to severe hyperkalemia.
- Spironolactone And Hydrochlorothiazide + Potassium Supplements— Concomitant administration may lead to severe hyperkalemia.
Moderate (10)
- Spironolactone And Hydrochlorothiazide + Acetylsalicylic Acid— May reduce efficacy of spironolactone; higher maintenance doses may be needed.
- Spironolactone And Hydrochlorothiazide + Acidifying Agents— Dosage adjustment of the antidiabetic drug may be required.
- Spironolactone And Hydrochlorothiazide + Alcohol— Potentiation of orthostatic hypotension may occur.
- Spironolactone And Hydrochlorothiazide + Barbiturates— Potentiation of orthostatic hypotension may occur.
- Spironolactone And Hydrochlorothiazide + Corticosteroids— Intensified electrolyte depletion, particularly hypokalemia, may occur.
- Spironolactone And Hydrochlorothiazide + Hydrochlorothiazide— Pressor amines (e.g., norepinephrine) Both spironolactone and hydrochlorothiazide reduce the vascular responsiveness to …
- Spironolactone And Hydrochlorothiazide + Insulin Human— Dosage adjustment of the antidiabetic drug may be required.
- Spironolactone And Hydrochlorothiazide + Norepinephrine— Both spironolactone and hydrochlorothiazide reduce vascular responsiveness to norepinephrine; caution during anesthesia.
- Spironolactone And Hydrochlorothiazide + Repository Corticotropin— Intensified electrolyte depletion, particularly hypokalemia, may occur.
- Spironolactone And Hydrochlorothiazide + Tubocurarine— Possible increased responsiveness to the muscle relaxant may result.