Does Spironolactone And Hydrochlorothiazide Interact with Mitotane?
CDI records a contraindicated classification for Spironolactone And Hydrochlorothiazide and Mitotane. The stored summary is: Avoid concomitant use; spironolactone reduces mitotane plasma levels. The mechanism involves reduced mitotane bioavailability. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Spironolactone And Hydrochlorothiazide Class
- Thiazide Diuretic
- Mitotane Class
- Cytochrome P450 3A4 Inducers
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced mitotane bioavailability
What To Tell Your Doctor or Pharmacist
If you are taking Spironolactone And Hydrochlorothiazide and your doctor is considering prescribing Mitotane (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider