Does Varicella Vaccine Interact with Human Immunoglobulin G?
Varicella Vaccine and Human Immunoglobulin G have a moderate drug interaction according to U.S. FDA drug labeling data. Immunoglobulin may transiently impair efficacy of live attenuated varicella vaccine due to interference with active antibody response from passively acquired antibodies. The mechanism involves passive antibodies interfere with active immune response to live vaccine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Human Immunoglobulin G Class
- Human Immunoglobulin G
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Varicella Vaccine and Human Immunoglobulin G occurs because passive antibodies interfere with active immune response to live vaccine. Clinically, this means immunoglobulin may transiently impair efficacy of live attenuated varicella vaccine due to interference with active antibody response from passively acquired antibodies. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Varicella Vaccine and your doctor is considering prescribing Human Immunoglobulin G (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider