Does Voriconazole Interact with Lumacaftor And Ivacaftor?
Voriconazole and Lumacaftor And Ivacaftor have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP3A inhibitor may increase ivacaftor exposure. Dosage adjustment recommended when initiating ORKAMBI. The mechanism involves cyp3a inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Voriconazole Class
- Azole Antifungal
- Lumacaftor And Ivacaftor Class
- Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Voriconazole and Lumacaftor And Ivacaftor occurs because cyp3a inhibition. Clinically, this means strong cyp3a inhibitor may increase ivacaftor exposure. dosage adjustment recommended when initiating orkambi. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Voriconazole and your doctor is considering prescribing Lumacaftor And Ivacaftor (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider