Does Warfarin Interact with Ezetimibe?
Warfarin and Ezetimibe have a moderate drug interaction according to U.S. FDA drug labeling data. If ezetimibe is added to warfarin (a coumarin anticoagulant), the International Normalized Ratio (INR) should be appropriately monitored. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Ezetimibe Class
- Dietary Cholesterol Absorption Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Warfarin and your doctor is considering prescribing Ezetimibe (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider