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Does Spironolactone And Hydrochlorothiazide Interact with Indomethacin?

Spironolactone And Hydrochlorothiazide and Indomethacin have a major drug interaction according to U.S. FDA drug labeling data. Combination with potassium-sparing diuretics has been associated with severe hyperkalemia; may reduce diuretic effects. The mechanism involves hyperkalemia risk and reduced diuretic efficacy. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Spironolactone And Hydrochlorothiazide Class
Thiazide Diuretic
Indomethacin Class
Nonsteroidal Anti-inflammatory Drug
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Spironolactone And Hydrochlorothiazide and Indomethacin occurs because hyperkalemia risk and reduced diuretic efficacy. Clinically, this means combination with potassium-sparing diuretics has been associated with severe hyperkalemia; may reduce diuretic effects. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Spironolactone And Hydrochlorothiazide and your doctor is considering prescribing Indomethacin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Spironolactone And Hydrochlorothiazide(Spironolactone And Hydrochlorothiazide)+💊 Indomethacin(Indomethacin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
Nonsteroidal Anti-inflammatory Drug
Source
NLP:spironolactone and hydrochlorothiazide

What this means in plain English

Combination with potassium-sparing diuretics has been associated with severe hyperkalemia; may reduce diuretic effects.

What the FDA label says

"Hyperkalemia risk and reduced diuretic efficacy"

📖 Source: NLP:spironolactone and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.