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Does Spironolactone And Hydrochlorothiazide Interact with Tubocurarine?

Spironolactone And Hydrochlorothiazide and Tubocurarine have a moderate drug interaction according to U.S. FDA drug labeling data. Possible increased responsiveness to the muscle relaxant may result. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Spironolactone And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Spironolactone And Hydrochlorothiazide and your doctor is considering prescribing Tubocurarine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Spironolactone And Hydrochlorothiazide(Spironolactone And Hydrochlorothiazide)+💊 Tubocurarine

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
—
Source
NLP:spironolactone and hydrochlorothiazide

What this means in plain English

Possible increased responsiveness to the muscle relaxant may result.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.