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Does Andexanet Alfa Interact with Heparin?

Andexanet Alfa and Heparin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Unresponsiveness to unfractionated heparin following ANDEXANET ALFA administration, characterized by non-prolongation of activated clotting times and requirement for increased heparin dosing. Do not use unfractionated heparin following ANDEXANET ALFA administration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Andexanet Alfa and your doctor is considering prescribing Heparin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Andexanet Alfa(Andexxa)+💊 Heparin(Defencath)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:andexanet alfa

What this means in plain English

Unresponsiveness to unfractionated heparin following ANDEXANET ALFA administration, characterized by non-prolongation of activated clotting times and requirement for increased heparin dosing. Do not use unfractionated heparin following ANDEXANET ALFA administration.

About Andexanet Alfa and Heparin

You may recognize them by the brand names Andexxa and Defencath. Andexanet Alfa is given by intravenous (IV) infusion. Andexanet Alfa additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.