Andexanet Alfa + Heparin Sodium Interaction
Majorinteraction on record
Description
Andexanet binds to heparin-bound antithrombin III and may reduce heparin's anticoagulant effect, potentially leading to serious and life-threatening thrombotic events. Avoid heparin use after andexanet alfa for Factor Xa inhibitor reversal.
Mechanism
Binding to heparin-bound antithrombin III reduces anticoagulant effect
Source: NLP:heparin sodium