Does Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra Interact with Mao Inhibitors?
Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra and Mao Inhibitors have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, aortic dissection, and renal failure. Do not use concomitantly or within 14 days after discontinuing MAOI. The mechanism involves direct interaction between maois and cns stimulants. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra and Mao Inhibitors occurs because direct interaction between maois and cns stimulants. Clinically, this means concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, aortic dissection, and renal failure. do not use concomitantly or within 14 days after discontinuing maoi. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Dextroamphetamine Saccharate Amphetamine Aspartate Monohydra and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider