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Does Diclofenac Sodium And Menthol Methyl Salicylate Interact with Pemetrexed?

Diclofenac Sodium And Menthol Methyl Salicylate and Pemetrexed have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Pemetrexed Class
Folate Analog Metabolic Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diclofenac Sodium And Menthol Methyl Salicylate and your doctor is considering prescribing Pemetrexed (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Diclofenac Sodium And Menthol Methyl Salicylate(Torvex)+💊 Pemetrexed(Pemfexy)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Folate Analog Metabolic Inhibitor
Source
NLP:diclofenac sodium, methyl salicylate

What this means in plain English

Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.

About Diclofenac Sodium And Menthol Methyl Salicylate and Pemetrexed

Pemetrexed is a Folate Analog Metabolic Inhibitor. You may recognize them by the brand names Torvex and Pemfexy. Diclofenac Sodium And Menthol Methyl Salicylate is applied to the skin, whereas Pemetrexed is given by intravenous (IV) infusion. Diclofenac Sodium And Menthol Methyl Salicylate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.