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Does Drugs That Prolong Qtc Interval Interact with Lonafarnib?

Drugs That Prolong Qtc Interval and Lonafarnib have a major drug interaction according to U.S. FDA drug labeling data. Avoid concomitant use. Lonafarnib causes QTc prolongation; combined use may result in greater QTc interval increase and serious arrhythmias including Torsade de pointes and sudden death. The mechanism involves additive qtc prolongation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Lonafarnib Class
Farnesyltransferase Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Drugs That Prolong Qtc Interval and Lonafarnib occurs because additive qtc prolongation. Clinically, this means avoid concomitant use. lonafarnib causes qtc prolongation; combined use may result in greater qtc interval increase and serious arrhythmias including torsade de pointes and sudden death. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Drugs That Prolong Qtc Interval and your doctor is considering prescribing Lonafarnib (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Drugs That Prolong Qtc Interval+💊 Lonafarnib(Zokinvy)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Farnesyltransferase Inhibitor
Source
NLP:lonafarnib

What this means in plain English

Avoid concomitant use. Lonafarnib causes QTc prolongation; combined use may result in greater QTc interval increase and serious arrhythmias including Torsade de pointes and sudden death.

What the FDA label says

"Additive QTc prolongation"

📖 Source: NLP:lonafarnib

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.