Lorlatinib + Fluconazole Interaction
Majorinteraction on record
Description
( 2.4 , 7.1 ) • Fluconazole : Avoid concomitant use; reduce LORBRENA dose if concomitant use cannot be avoided. Fluconazole Avoid concomitant use of LORBRENA with fluconazole. Concomitant use of LORBRENA with fluconazole may increase lorlatinib plasma concentrations [see Clinical Pharmacology (12.3) ] , which may increase the incidence and severity of adverse reactions of LORBRENA.
Source: FDA drug label - lorlatinib