Does Lumacaftor And Ivacaftor Interact with Levofloxacin?
Lumacaftor And Ivacaftor and Levofloxacin have a unknown drug interaction according to U.S. FDA drug labeling data. Consider an alternative to these antibiotics, such as ciprofloxacin, azithromycin, and levofloxacin. 7.15 Concomitant Drugs That Do Not Need Dosage Adjustment No dosage adjustment of ORKAMBI or concomitant drug is recommended when ORKAMBI is given with the following: azithromycin, aztreonam, budesonide, ceftazidime, cetirizine, ciprofloxacin, colistimethate, colistin, dornase alfa, fluticasone, ipratropium, levofloxacin, pancreatin, pancrelipase, salbutamol, salmeterol, sulfamethoxazole, trimethoprim, tiotropium, and tobramycin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Lumacaftor And Ivacaftor Class
- Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
- Levofloxacin Class
- Fluoroquinolone Antibacterial
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Lumacaftor And Ivacaftor and your doctor is considering prescribing Levofloxacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider