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Does Lumacaftor And Ivacaftor Interact with Methylprednisolone?

Lumacaftor And Ivacaftor and Methylprednisolone have a unknown drug interaction according to U.S. FDA drug labeling data. Concomitant use of ORKAMBI may reduce the exposure and effectiveness of prednisone and methylprednisolone. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Lumacaftor And Ivacaftor Class
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Methylprednisolone Class
Corticosteroid
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Lumacaftor And Ivacaftor and your doctor is considering prescribing Methylprednisolone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lumacaftor And Ivacaftor(Orkambi)+💊 Methylprednisolone(HybriSil)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Drug B class
Corticosteroid
Source
FDA drug label - lumacaftor and ivacaftor

What this means in plain English

Concomitant use of ORKAMBI may reduce the exposure and effectiveness of prednisone and methylprednisolone.

About Lumacaftor And Ivacaftor and Methylprednisolone

Lumacaftor And Ivacaftor is a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, while Methylprednisolone is a Corticosteroid. You may recognize them by the brand names Orkambi and HybriSil. Lumacaftor And Ivacaftor is taken by mouth, whereas Methylprednisolone is given by intramuscular injection.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.